Cytokine Profile in Early Infection by Leptospira interrogans in A/J Mice.

ABSTRACT: Leptospirosis is considered a neglected disease with an estimated more than one million cases every year. Since rodents are at the same time the main reservoir and generally asymptomatic to Leptospira infection, understanding why some animal species are resistant and others are susceptible to this infection would shed some light in how to control this important zoonosis. The innate immune response against Leptospira is mainly dependent on phagocytosis and activation of the Complement System. In this context, cytokines may drive the early control of infection and the adaptive response. Since the Complement System is important to eliminate leptospires in vivo, we investigated if Complement C5 in A/J mice would modulate the cytokine production during infection by Lepto

SUBMITTER: Bavia L 

PROVIDER: S-EPMC6800925 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature