Identification of key genes and multiple molecular pathways of metastatic process in prostate cancer.

ABSTRACT:

Background

Cancer metastasis is well known as the most adverse outcome and the major cause of mortality in cancer patients, including prostate cancer (PCa). There are no credible predictors, to this day, that can reflect the metastatic ability of localized PCa. In the present study, we firstly identified the differentially expressed genes (DEGs) and molecular pathways involved in the metastaic process of PCa by comparing gene expressions of metastaic PCa with localized PCa directly, with the purpose of identifying potential markers or therapeutic targets.

Methods

The gene expression profiles (GSE6919 and GSE32269) were downloaded from the Gene Expression Omnibus database, which contained 141 tissue samples, including 87 primary localized PCa samples and 54 metastaic PCa samp

SUBMITTER: Guo L 

PROVIDER: S-EPMC6800981 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature