Yy1 regulates Senp1 contributing to AMPA receptor GluR1 expression following neuronal depolarization.

ABSTRACT: BACKGROUND:Neuronal activity-induced changes in gene expression patterns are important mediators of neuronal plasticity. Many neuronal genes can be activated or inactivated in response to neuronal depolarization. Mechanisms that activate gene transcription are well established, but activity-dependent mechanisms that silence transcription are less understood. It is also not clear what is the significance of inhibiting these genes during neuronal activity. METHODS:Quantitative Real Time-PCR, western blot and immunofluorescence staining were performed to examine the expression of Senp1 and GluR1 in mouse cortical neurons. The alterations of Yy1 phosphorylation upon neuronal depolarization and the interaction of Yy1 with Brd4 were studied by protein co-immunoprecipitation. The regulators of Yy

SUBMITTER: Wu T 

PROVIDER: S-EPMC6800989 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature