Evidence of reward system dysfunction in youth at clinical high-risk for psychosis from two event-related fMRI paradigms.

ABSTRACT: Abnormal reward processing is thought to play an important role in the development of psychosis, but relatively few studies have examined reward prediction errors, reinforcement learning (RL), and the reward circuitry that subserves these interconnected processes among individuals at clinical high-risk (CHR) for the disorder. Here, we present behavioral and functional neuroimaging results of two experimental tasks designed to measure overlapping aspects of reward processing among individuals at CHR (n = 22) and healthy controls (n = 19). We found no group differences in response times to positive, negative, or neutral outcome-signaling cues, and no significant differences in brain activation during reward anticipation or receipt. Youth at CHR, however, displayed clear RL impairments, as we

SUBMITTER: Millman ZB 

PROVIDER: S-EPMC6801019 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature