Hydrogen sulfide-releasing peptide hydrogel limits the development of intimal hyperplasia in human vein segments.

ABSTRACT: Currently available interventions for vascular occlusive diseases suffer from high failure rates due to re-occlusive vascular wall adaptations, a process called intimal hyperplasia (IH). Naturally occurring hydrogen sulfide (H₂S) works as a vasculoprotective gasotransmitter in vivo. However, given its reactive and hazardous nature, H₂S is difficult to administer systemically. Here, we developed a hydrogel capable of localized slow release of precise amounts of H₂S and tested its benefits on IH. The H₂S-releasing hydrogel was prepared from a short peptide attached to an S-aroylthiooxime H₂S donor. Upon dissolution in aqueous buffer, the peptide self-assembled into nanofibers, which formed a gel in the presence of calcium. This new hydro

SUBMITTER: Longchamp A 

PROVIDER: S-EPMC6801028 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature