Genetics of diabetic neuropathy: Systematic review, meta-analysis and trial sequential analysis.

ABSTRACT:

Objective

Diabetic neuropathy (DN) is one of the most common complications of diabetes that occurs in more than 67% of individuals with diabetes. Genetic polymorphisms may play an important role in DN development. However, until now, the association between genetic polymorphisms and DN risk has remained unknown. We performed a systematic review, meta-analysis, and trial sequential analysis (TSA) of the association between all genetic polymorphisms and DN risk.

Methods

Relevant published studies examining the relationship between all genetic polymorphisms and DN were obtained based on a designed search strategy up to 28 February 2019. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess overall pooled effects of genetic models as well as in subgroup

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC6801182 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature