Robust Sampling of Defective Pathways in Multiple Myeloma.

ABSTRACT: We present the analysis of defective pathways in multiple myeloma (MM) using two recently developed sampling algorithms of the biological pathways: The Fisher's ratio sampler, and the holdout sampler. We performed the retrospective analyses of different gene expression datasets concerning different aspects of the disease, such as the existing difference between bone marrow stromal cells in MM and healthy controls (HC), the gene expression profiling of CD34+ cells in MM and HC, the difference between hyperdiploid and non-hyperdiploid myelomas, and the prediction of the chromosome 13 deletion, to provide a deeper insight into the molecular mechanisms involved in the disease. Our analysis has shown the importance of different altered pathways related to glycosylation, infectious disease, immu

SUBMITTER: Fernandez-Martinez JL 

PROVIDER: S-EPMC6801400 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature