Genome-Wide CpG Island Methylation Profiles of Cutaneous Skin with and without HPV Infection.

ABSTRACT: HPV infection is one of the most commonly transmitted diseases among the global population. While it can be asymptomatic, non-genital HPV infection often gives rise to cutaneous warts, which are benign growths arising from the epidermal layer of the skin. This study aimed to produce a global analysis of the ways in which cutaneous wart formation affected the CpG island methylome. The Infinium MethylationEPIC BeadChip microarray was utilized in order to quantitatively interrogate CpG island methylation in genomic DNA extracted from 24 paired wart and normal skin samples. Differential methylation analysis was carried out by means of assigning a combined rank score using RnBeads. The 1000 top-ranking CpG islands were then subject to Locus Overlap Analysis (LOLA) for enrichment of genomic rang

SUBMITTER: Al-Eitan LN 

PROVIDER: S-EPMC6801420 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature