Pharmacological Targeting of GLUT1 to Control Autoreactive T Cell Responses.

ABSTRACT: An increasing body of evidence indicates that bio-energetic metabolism of T cells can be manipulated to control T cell responses. This potentially finds a field of application in the control of the T cell responses in autoimmune diseases, including in type 1 diabetes (T1D). Of the possible metabolic targets, Glut1 gained considerable interest because of its pivotal role in glucose uptake to fuel glycolysis in activated T cells, and the recent development of a novel class of small molecules that act as selective inhibitor of Glut1. We believe we can foresee a possible application of pharmacological Glut1 blockade approach to control autoreactive T cells that destroy insulin producing beta cells. However, Glut1 is expressed in a broad range of cells in the body and off-target and side effect

SUBMITTER: Di Dedda C 

PROVIDER: S-EPMC6801424 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature