New Insights into Immunotherapy Strategies for Treating Autoimmune Diabetes.

ABSTRACT: Type 1 diabetes mellitus (T1D) is an autoimmune illness that affects millions of patients worldwide. The main characteristic of this disease is the destruction of pancreatic insulin-producing beta cells that occurs due to the aberrant activation of different immune effector cells. Currently, T1D is treated by lifelong administration of novel versions of insulin that have been developed recently; however, new approaches that could address the underlying mechanisms responsible for beta cell destruction have been extensively investigated. The strategies based on immunotherapies have recently been incorporated into a panel of existing treatments for T1D, in order to block T-cell responses against beta cell antigens that are very common during the onset and development of T1D. However, a comple

SUBMITTER: Cabello-Olmo M 

PROVIDER: S-EPMC6801436 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature