Chirality-Dependent Adsorption between Amphipathic Peptide and POPC Membrane.

ABSTRACT: The interactions between chiral molecules and cell membranes have attracted more and more attention in recent decades, due to their importance in molecular science and medical applications. It is observed that some peptides composed of different chiral amino acids may have distinct interactions with a membrane. How does the membrane exhibit a selective behavior related to the chirality of the peptides? Microscopically, the interactions between the peptides and the membrane are poorly understood. In this work, we study the interactions between an amphipathic peptide (C6) and POPC membrane with simulations. The kinetics and thermodynamics of peptide enantiomers during the adsorption to the membrane are characterized with direct simulations and umbrella sampling. It is observed that there are

SUBMITTER: Chen K 

PROVIDER: S-EPMC6801444 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature