Human Leukocyte Antigen and Red Blood Cells Impact Umbilical Cord Blood CD34⁺ Cell Viability after Thawing.

ABSTRACT: Hematopoietic progenitor cell (HPC) transplantation is a treatment option for malignant and nonmalignant diseases. Umbilical cord blood (UCB) is an important HPC source, mainly for pediatric patients. It has been demonstrated that human leukocyte antigen (HLA) matching and cell dose are the most important features impacting clinical outcomes. However, UCB matching is performed using low resolution HLA typing and it has been demonstrated that the unnoticed mismatches negatively impact the transplant. Since we found differences in CD34⁺ viability after thawing of UCB units matched for two different patients (p = 0.05), we presumed a possible association between CD34⁺ cell viability and HLA. We performed a multivariate linear model (n = 67), comprising pre-

SUBMITTER: Vanegas D 

PROVIDER: S-EPMC6801469 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature