Fibroblast Growth Factor 21 and the Adaptive Response to Nutritional Challenges.

ABSTRACT: The Fibroblast Growth Factor 21 (FGF21) is considered an attractive therapeutic target for obesity and obesity-related disorders due to its beneficial effects in lipid and carbohydrate metabolism. FGF21 response is essential under stressful conditions and its metabolic effects depend on the inducer factor or stress condition. FGF21 seems to be the key signal which communicates and coordinates the metabolic response to reverse different nutritional stresses and restores the metabolic homeostasis. This review is focused on describing individually the FGF21-dependent metabolic response activated by some of the most common nutritional challenges, the signal pathways triggering this response, and the impact of this response on global homeostasis. We consider that this is essential knowledge to

SUBMITTER: Martinez-Garza U 

PROVIDER: S-EPMC6801670 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature