Human Cysteine Cathepsins Degrade Immunoglobulin G In Vitro in a Predictable Manner.

ABSTRACT: Cysteine cathepsins are critical components of the adaptive immune system involved in the generation of epitopes for presentation on human leukocyte antigen (HLA) molecules and have been implicated in degradation of autoantigens. Immunoglobulin variable regions with somatic mutations and random complementarity region 3 amino acid composition are inherently immunogenic. T cell reactivity towards immunoglobulin variable regions has been investigated in relation to specific diseases, as well as reactivity to therapeutic monoclonal antibodies. Yet, how the immunoglobulins, or the B cell receptors, are processed in endolysosomal compartments of professional antigen presenting cells has not been described in detail. Here we present in silico and in vitro experimental evidence suggesting that cys

SUBMITTER: Hoglund RA 

PROVIDER: S-EPMC6801702 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature