Type XVIII Collagen Modulates Keratohyalin Granule Formation and Keratinization in Oral Mucosa.

ABSTRACT: Epithelial keratinization involves complex cellular modifications that provide protection against pathogens and chemical and mechanical injuries. In the oral cavity, keratinized mucosa is also crucial to maintain healthy periodontal or peri-implant tissues. In this study, we investigated the roles of type XVIII collagen, a collagen-glycosaminoglycan featuring an extracellular matrix component present in the basement membrane, in oral mucosal keratinization. Histological analysis of keratinized and non-keratinized oral mucosa showed that type XVIII collagen was highly expressed in keratinized mucosa. Additionally, a 3D culture system using human squamous carcinoma cells (TR146) was used to evaluate and correlate the changes in the expression of type XVIII collagen gene, COL18A1, and epithel

SUBMITTER: Nguyen HTT 

PROVIDER: S-EPMC6801805 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature