Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC6801969 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Wang Junjun J Liu Juanjuan J Ji Xinmiao X Zhang Xin X
International journal of molecular sciences 20190930 19
STK16, reported as a Golgi localized serine/threonine kinase, has been shown to participate in multiple cellular processes, including the TGF-β signaling pathway, TGN protein secretion and sorting, as well as cell cycle and Golgi assembly regulation. However, the mechanisms of the regulation of its kinase activity remain underexplored. It was known that STK16 is autophosphorylated at Thr185, Ser197, and Tyr198 of the activation segment in its kinase domain. We found that STK16 localizes to the c ...[more]