Green oxidation of indoles using halide catalysis.

ABSTRACT: Oxidation of indoles is a fundamental organic transformation to deliver a variety of synthetically and pharmaceutically valuable nitrogen-containing compounds. Prior methods require the use of either organic oxidants (meta-chloroperoxybenzoic acid, N-bromosuccinimide, t-BuOCl) or stoichiometric toxic transition metals [Pb(OAc)₄, OsO₄, CrO₃], which produced oxidant-derived by-products that are harmful to human health, pollute the environment and entail immediate purification. A general catalysis protocol using safer oxidants (H₂O₂, oxone, O₂) is highly desirable. Herein, we report a unified, efficient halide catalysis for three oxidation reactions of indoles using oxone as the terminal oxidant, namely oxidative rearrangement

SUBMITTER: Xu J 

PROVIDER: S-EPMC6802211 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature