Feasibility of Using Real-World Data to Replicate Clinical Trial Evidence.

ABSTRACT:

Importance

Although randomized clinical trials are considered to be the criterion standard for generating clinical evidence, the use of real-world evidence to evaluate the efficacy and safety of medical interventions is gaining interest. Whether observational data can be used to address the same clinical questions being answered by traditional clinical trials is still unclear.

Objective

To identify the number of clinical trials published in high-impact journals in 2017 that could be feasibly replicated using observational data from insurance claims and/or electronic health records (EHRs).

Design, setting, and participants

In this cross-sectional analysis, PubMed was searched to identify all US-based clinical trials, regardless of randomization, published between Janua

SUBMITTER: Bartlett VL 

PROVIDER: S-EPMC6802419 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature