Risk of Developing Parkinson Disease in Bipolar Disorder: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Parkinson disease (PD) manifests by motor and nonmotor symptoms, which may be preceded by mood disorders by more than a decade. Bipolar disorder (BD) is characterized by cyclic episodes of depression and mania. It is also suggested that dopamine might be relevant in the pathophysiology of BD.

Objective

To assess the association of BD with a later diagnosis of idiopathic PD.

Data sources

An electronic literature search was performed of Cochrane Controlled Register of Trials, MEDLINE, Embase, and PsycINFO from database inception to May 2019 using the terms Parkinson disease, bipolar disorder, and mania, with no constraints applied.

Study selection

Studies that reported data on the likelihood of developing PD in BD vs non-BD populations were included. T

SUBMITTER: Faustino PR 

PROVIDER: S-EPMC6802493 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature