Protein structure prediction using Rosetta in CASP12.

ABSTRACT: We describe several notable aspects of our structure predictions using Rosetta in CASP12 in the free modeling (FM) and refinement (TR) categories. First, we had previously generated (and published) models for most large protein families lacking experimentally determined structures using Rosetta guided by co-evolution based contact predictions, and for several targets these models proved better starting points for comparative modeling than any known crystal structure-our model database thus starts to fulfill one of the goals of the original protein structure initiative. Second, while our "human" group simply submitted ROBETTA models for most targets, for six targets expert intervention improved predictions considerably; the largest improvement was for T0886 where we correctly parsed two dis

SUBMITTER: Ovchinnikov S 

PROVIDER: S-EPMC6802495 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature