Membrane-mediated fibrillation and toxicity of the tau hexapeptide PHF6.

ABSTRACT: The aggregation of the tau protein into neurofibrillary tangles is believed to correlate with cognitive decline in several neurodegenerative disorders, including Alzheimer's disease. Recent studies suggest that tau's interactions with the cell membrane could serve as a toxicity pathway and also enhance fibrillation into paired helical filaments (PHFs). Conformational changes associated with tau-membrane interactions are poorly understood, and their characterization could improve our understanding of tau pathogenicity. In this study, we investigated the molecular level structural changes associated with the interaction of the tau hexapeptide PHF6 with model lipid membranes and characterized the effects of these interactions on membrane stability and peptide fibrillation. We used two PHF6 fo

SUBMITTER: Fanni AM 

PROVIDER: S-EPMC6802503 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature