Ontology highlight
ABSTRACT:
SUBMITTER: Ko HR
PROVIDER: S-EPMC6802513 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20190830 42
Akt signaling is an important regulator of neural development, but the distinctive function of Akt isoforms in brain development presents a challenge. Here we show Siah1 as an ubiquitin ligase that preferentially interacts with Akt3 and facilitates ubiquitination and degradation of Akt3. Akt3 is enriched in the axonal shaft and branches but not growth cone tips, where Siah1 is prominently present. Depletion of Siah1 enhanced Akt3 levels in the soma and axonal tips, eliciting multiple branching. ...[more]