Circadian rhythm-dependent induction of hepatic lipogenic gene expression in rats fed a high-sucrose diet.

ABSTRACT: Metabolic syndrome has become a global health challenge and was recently reported to be positively correlated with increased sucrose consumption. Mechanistic analyses of excess sucrose-induced progression of metabolic syndrome have been focused mainly on abnormal hepatic lipogenesis, and the exact contribution of excess sucrose to metabolic disorders remains controversial. Considering that carbohydrate and lipid metabolisms exhibit clear circadian rhythms, here we investigated the possible contribution of diurnal oscillations to responses of hepatic lipid metabolism to excess sucrose. We found that excess sucrose dose-dependently promotes fatty liver and hyperlipidemia in in rats fed a high-sucrose diet (HSD). We observed that excess sucrose enhances the oscillation amplitudes of the expre

SUBMITTER: Sun S 

PROVIDER: S-EPMC6802514 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature