Methylation determines the extracellular calcium sensitivity of the leak channel NALCN in hippocampal dentate granule cells.

ABSTRACT: The sodium leak channel NALCN is a key player in establishing the resting membrane potential (RMP) in neurons and transduces changes in extracellular Ca²⁺ concentration ([Ca²⁺]_e) into increased neuronal excitability as the downstream effector of calcium-sensing receptor (CaSR). Gain-of-function mutations in the human NALCN gene cause encephalopathy and severe intellectual disability. Thus, understanding the regulatory mechanisms of NALCN is important for both basic and translational research. This study reveals a novel mechanism for NALCN regulation by arginine methylation. Hippocampal dentate granule cells in protein arginine methyltransferase 7 (PRMT7)-deficient mice display a depolarization of the RMP, decreased threshold currents, and increased excitabi

SUBMITTER: Lee SY 

PROVIDER: S-EPMC6802672 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature