Modeling the natural history of fatty liver using lifestyle-related risk factors: Effects of body mass index (BMI) on the life-course of fatty liver.

ABSTRACT: BACKGROUND:Incident fatty liver increases the risk of non-alcoholic fatty liver disease (NAFLD), which may lead to end-stage liver diseases, and increase the risk of cardiovascular disease and diabetes. For its prevention, modeling the natural history of fatty liver is useful to demonstrate which lifestyle-related risk factors (e.g. body mass index and cholesterol) play the greatest role in the life-course of fatty liver. METHODS:Model predictors and their predictive algorithms were determined by prospective regression analyses using 5-year data from approximately 2000 Japanese men aged 20-69 years. The participants underwent health examinations and completed questionnaires on their lifestyle behaviors annually from 2012 to 2016. The life-course of fatty liver was simulated based on this p

SUBMITTER: Aizawa M 

PROVIDER: S-EPMC6802837 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature