Ferumoxytol-enhanced MRI in patients with prior cardiac transplantation.

ABSTRACT:

Objectives

Ultra-small superparamagnetic particles of iron oxide (USPIO)-enhanced MRI can detect cellular inflammation within tissues and may help non-invasively identify cardiac transplant rejection. Here, we aimed to determine the normal reference values for USPIO-enhanced MRI in patients with a prior cardiac transplant and examine whether USPIO-enhanced MRI could detect myocardial inflammation in patients with transplant rejection.

Methods

Ten volunteers and 11 patients with cardiac transplant underwent T2, T2* and late gadolinium enhancement 1.5T MRI, with further T2* imaging at 24 hours after USPIO (ferumoxytol, 4 mg/kg) infusion, at baseline and 3 months.

Results

Ten patients with clinically stable cardiac transplantation were retained for analysis. Myocardial T

SUBMITTER: Stirrat CG 

PROVIDER: S-EPMC6802993 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature