Preorganized PSP Ligands Yield Monomeric Cu(I) Complexes with Subzeptomolar Cu(I) Dissociation Constants.

ABSTRACT: Unraveling the function of biological copper (Cu) requires tools that can selectively recognize and manipulate this trace nutrient within the complex chemical environment of biological systems. Increasing evidence suggests that cells maintain an exchangeable pool of Cu(I) that is buffered in the high zeptomolar to low attomolar range. While mixed amine-thioether donors have been commonly employed for the design of Cu(I)-selective ligands and probes, their dissociation constants are limited to the pico- to femtomolar range. To address this challenge, we combined our previously devised phosphine sulfide-stabilized phosphine donor motifs with a rigid 1,2-phenylene or 1,8-naphthylene ligand backbone. The resulting ligands, phenPS and naphPS, bind Cu(I) with a 1:1 complex stoichiometry and offe

SUBMITTER: Saeedifard F 

PROVIDER: S-EPMC6803021 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature