Specific class of intrapartum antibiotics relates to maturation of the infant gut microbiota: a prospective cohort study.

ABSTRACT:

Objective

To evaluate the potential impact of intrapartum antibiotics, and their specific classes, on the infant gut microbiota in the first year of life.

Design

Prospective study of infants in the New Hampshire Birth Cohort Study (NHBCS).

Settings

Rural New Hampshire, USA.

Population or sample

Two hundred and sixty-six full-term infants from the NHBCS.

Methods

Intrapartum antibiotic use during labour and delivery was abstracted from medical records. Faecal samples collected at 6 weeks and 1 year of age were characterised by 16S rRNA sequencing, and metagenomics analysis in a subset of samples.

Exposures

Maternal exposure to antibiotics during labour and delivery.

Main outcome measure

Taxonomic and functional profiles of faecal samples.

SUBMITTER: Coker MO 

PROVIDER: S-EPMC6803026 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature