Discontinuation of non-Vitamin K antagonist oral anticoagulants in patients with non-valvular atrial fibrillation: a population-based cohort study using primary care data from The Health Improvement Network in the UK.

ABSTRACT:

Objective

To determine discontinuation rates, patterns of use and predictors of discontinuation of non-vitamin K antagonist oral anticoagulants (NOACs) among patients with non-valvular atrial fibrillation (NVAF) in the first year of therapy.

Design

Population-based cohort study.

Setting

UK primary care.

Population

11 481 patients with NVAF and a first prescription (index date) for apixaban, dabigatran or rivaroxaban (January 2012 to December 2016) with at least 1 year of follow-up and at least one further NOAC prescription in the year following the index date were identified. 1 year rates and patterns of discontinuation were described.

Primary and secondary outcome measures

Outcome measures were the percentage of patients who, in the first year from star

SUBMITTER: Ruigomez A 

PROVIDER: S-EPMC6803078 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature