Serum biomarkers in patients suspected of transient ischaemic attack in primary care: a diagnostic accuracy study.

ABSTRACT:

Objective

The diagnosis of transient ischaemic attack (TIA) based on symptoms and signs can be challenging and would greatly benefit from a rapid serum biomarker of brain ischaemia. We aimed to quantify the added diagnostic value of serum biomarkers in patients suspected of TIA beyond symptoms and signs.

Methods

This is a cross-sectional diagnostic accuracy study with a 6-month follow-up period. Participants were patients suspected of TIA by the general practitioner (GP) in whom a blood sample could be collected within 72 hours from symptom onset. A research nurse visited the participant for the blood sample and a standardised interview. The GP referred participants to the regional TIA service. An expert panel of three neurologists classified cases as TIA, minor stroke or an

SUBMITTER: Dolmans LS 

PROVIDER: S-EPMC6803126 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature