Fine mapping of thyroglobulin gene identifies two independent risk loci for Graves' disease in Chinese Han population.

ABSTRACT:

Background

This study aimed to determine independent risk loci of Graves' disease (GD) in the thyroglobulin (TG) region.

Methods

In this two-staged association study, a total of 9,757 patients with GD and 10,626 sex-matched controls were recruited from Chinese Han population. Illumina Human660-Quad BeadChips in the discovery stage and TaqMan SNP Genotyping Assays in the replication stage were used for genotyping. Trend test and logistic regression analysis were performed in this association study.

Results

In the discovery stage, rs2294025 and rs7005834 were the most highly associated susceptibility loci with GD in TG. In the replication phase, 7 SNPs, including rs2294025 and rs7005834, were selected for fine-mapping. Finally, we confirmed that rs2294025 and rs7

SUBMITTER: Xuan M 

PROVIDER: S-EPMC6803187 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature