Human Cytomegalovirus pUL37x1 Is Important for Remodeling of Host Lipid Metabolism.

ABSTRACT: Human cytomegalovirus (HCMV) replication requires host metabolism. Infection alters the activity in multiple metabolic pathways, including increasing fatty acid elongation and lipid synthesis. The virus-host interactions regulating the metabolic changes associated with replication are essential for infection. While multiple host factors, including kinases and transcription factors, important for metabolic changes that occur following HCMV infection have been identified, little is known about the viral factors required to alter metabolism. In this study, we tested the hypothesis that pUL37x1 is important for the metabolic remodeling that is necessary for HCMV replication using a combination of metabolomics, lipidomics, and metabolic tracers to measure fatty acid elongation. We observed that

SUBMITTER: Xi Y 

PROVIDER: S-EPMC6803270 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature