Identification of Novel Bacteriophages with Therapeutic Potential That Target Enterococcus faecalis.

ABSTRACT: The Gram-positive opportunistic pathogen Enterococcus faecalis is frequently responsible for nosocomial infections in humans and represents one of the most common bacteria isolated from recalcitrant endodontic (root canal) infections. E. faecalis is intrinsically resistant to several antibiotics routinely used in clinical settings (such as cephalosporins and aminoglycosides) and can acquire resistance to vancomycin (vancomycin-resistant enterococci). The resistance of E. faecalis to several classes of antibiotics and its capacity to form biofilms cause serious therapeutic problems. Here, we report the isolation of several bacteriophages that target E. faecalis strains isolated from the oral cavity of patients suffering root canal infections. All phages isolated

SUBMITTER: Al-Zubidi M 

PROVIDER: S-EPMC6803325 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature