C. elegans synMuv B proteins regulate spatial and temporal chromatin compaction during development.

ABSTRACT: Tissue-specific establishment of repressive chromatin through creation of compact chromatin domains during development is necessary to ensure proper gene expression and cell fate. Caenorhabditis elegans synMuv B proteins are important for the soma/germline fate decision and mutants demonstrate ectopic germline gene expression in somatic tissue, especially at high temperature. We show that C. elegans synMuv B proteins regulate developmental chromatin compaction and that the timing of chromatin compaction is temperature sensitive in both wild type and synMuv B mutants. Chromatin compaction in mutants is delayed into developmental time periods when zygotic gene expression is upregulated and demonstrates an anterior-to-posterior pattern. Loss of this patterned compaction coincides with the dev

SUBMITTER: Costello ME 

PROVIDER: S-EPMC6803374 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature