Circulating neurofilament light in ischemic stroke: temporal profile and outcome prediction.

ABSTRACT:

Background and purpose

Neurofilament light chain (NfL) is a marker of neuroaxonal damage. We aimed to study associations between serum NfL (sNfL) concentrations at different time points after ischemic stroke and outcomes.

Methods

We prospectively included ischemic stroke cases (n = 595, mean age 59 years, 64% males) and assessed outcomes by both the modified Rankin Scale (mRS) and the NIH stroke scale (NIHSS) at 3 months and by mRS at 2 years. In a subsample, long-term (7-year) outcomes were also assessed by both mRS and NIHSS. We used the ultrasensitive single-molecule array assay to measure sNfL in the acute phase (range 1-14, median 4 days), after 3 months and 7 years in cases and once in controls (n = 595).

Results

Acute-phase sNfL increased by the time to blood-d

SUBMITTER: Pedersen A 

PROVIDER: S-EPMC6803587 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature