NMR-based metabolomics in pediatric drug resistant epilepsy - preliminary results.

ABSTRACT: Epilepsy in children is the most frequent, heterogeneous and difficult to classify chronic neurologic condition with the etiology found in 35-40% of patients. Our aim is to detect the metabolic differences between the epileptic children and the children with no neurological abnormalities in order to define the metabolic background for therapy monitoring. The studied group included 28 epilepsy patients (median age 12 months) examined with a diagnostic protocol including EEG, videoEEG, 24-hour-EEG, tests for inborn errors of metabolism, chromosomal analysis and molecular study. The reference group consisted of 20 patients (median age 20 months) with no neurological symptoms, no development delay nor chronic diseases. ¹H-NMR serum spectra were acquired on 400 MHz spectrometer and a

SUBMITTER: Boguszewicz L 

PROVIDER: S-EPMC6803684 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature