Cell-Type-Specific Transcription of Innate Immune Regulators in response to HMPV Infection.

ABSTRACT: Human metapneumovirus (HMPV) may cause severe respiratory disease. The early innate immune response to viruses like HMPV is characterized by induction of antiviral interferons (IFNs) and proinflammatory immune mediators that are essential in shaping adaptive immune responses. Although innate immune responses to HMPV have been comprehensively studied in mice and murine immune cells, there is less information on these responses in human cells, comparing different cell types infected with the same HMPV strain. The aim of this study was to characterize the HMPV-induced mRNA expression of critical innate immune mediators in human primary cells relevant for airway disease. In particular, we determined type I versus type III IFN expression in human epithelial cells and monocyte-derived macrophage

SUBMITTER: Loevenich S 

PROVIDER: S-EPMC6803734 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature