The proteasome regulator PTRE1 contributes to the turnover of SNC1 immune receptor.

ABSTRACT: Plants have evolved a sophisticated immune system in order to recognize and respond to microbes in their environments. Nucleotide-binding leucine-rich repeat (NLR) proteins detect the presence of specific effector molecules delivered into host cells by pathogens and activate strong defence responses. However, as excessive accumulation of NLRs can result in inappropriate immune responses, their abundance must be tightly regulated. Targeted degradation of NLRs through the ubiquitin proteasome pathway is an important mechanism to limit NLR accumulation. Mutations that perturb NLR degradation can cause autoimmune phenotypes. In this study, we show that the proteasome regulator PTRE1 also contributes to NLR degradation. ptre1 mutant plants exhibit increased defence marker gene expression and en

SUBMITTER: Thulasi Devendrakumar K 

PROVIDER: S-EPMC6804346 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature