Infection and vaccine-induced HPV-specific antibodies in cervicovaginal secretions. A review of the literature.

ABSTRACT: BACKGROUND:Human papillomavirus (HPV) infects and propagates in the cervical mucosal epithelium. Hence, in addition to assessing systemic immunity, the accurate measurement of cervical immunity is important to evaluate local immune responses to HPV infection and vaccination. This review discusses studies that investigated the presence of infection and vaccine-induced HPV-specific antibodies in cervicovaginal secretions (CVS). METHODS:We searched the two main health sciences databases, PubMed and the ISI Web of Science, from the earliest dates available to March 2019. From the eligible publications, information was extracted regarding: (i) study design, (ii) the reported HPV-specific antibody concentrations in CVS (and the associated serum levels, when provided), (iii) the CVS collection me

SUBMITTER: Pattyn J 

PROVIDER: S-EPMC6804463 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature