Hs-CRP Is Associated With Incident Diabetic Nephropathy: Findings From the Jackson Heart Study.

ABSTRACT:

Objective

African Americans (AA) suffer disproportionately from diabetic nephropathy (DN). C-reactive protein (CRP) has been associated with prevalent DN, but its association with incident DN in AA is unknown. We examined hs-CRP and incident DN in AA.

Research design and methods

We conducted a longitudinal analysis of data from exams 1, 2, and 3 in 4,043 eligible Jackson Heart Study (JHS) participants. Participants with DN or without hs-CRP at exam 1 were excluded. Incident DN was defined as urinary albumin-to-creatinine ratio (ACR) >30 mg/g or self-reported dialysis/transplantation and type 2 diabetes mellitus (DM) or HbA_1c >6.5% by exam 2 or 3 among participants free of DN at exam 1. Kaplan-Meier curves examined DN event-free survival probability by hs-CRP. With

SUBMITTER: Sinha SK 

PROVIDER: S-EPMC6804609 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature