Baseline Characteristics of Randomized Participants in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).

ABSTRACT:

Objective

GRADE (Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study) is a 36-center unmasked, parallel treatment group, randomized controlled trial evaluating four diabetes medications added to metformin in people with type 2 diabetes (T2DM). We report baseline characteristics and compare GRADE participants to a National Health and Nutrition Examination Survey (NHANES) cohort.

Research design and methods

Participants were age ≥30 years at the time of diagnosis, with duration of T2DM <10 years, HbA_1c 6.8-8.5% (51-69 mmol/mol), prescribed metformin monotherapy, and randomized to glimepiride, sitagliptin, liraglutide, or insulin glargine.

Results

At baseline, GRADE's 5,047 randomized participants were 57.2 ± 10.0 years of age, 63.6% m

SUBMITTER: Wexler DJ 

PROVIDER: S-EPMC6804613 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature