Latent class analysis identifies functional decline with Amsterdam IADL in preclinical Alzheimer's disease.

ABSTRACT:

Introduction

Trials in Alzheimer's disease (AD) now include participants at the earliest stages to prevent further decline. However, the lack of tools sensitive to subtle functional changes in early-stage AD hinders the development of new therapies as it is difficult to prove their clinical relevance.

Methods

We assessed functional changes over three years in 289 elderly memory complainers from the Investigation of Alzheimer's Predictors in subjective memory complainers cohort using the Amsterdam Instrumental-Activities-of-Daily-Living questionnaire (A-IADL-Q).

Results

No overall functional decline related to AD imaging markers was evidenced. However, five distinct classes of A-IADL-Q trajectories were identified. The largest class (212 [73.4%]) had stable A-IADL-Q sc

SUBMITTER: Villeneuve SC 

PROVIDER: S-EPMC6804616 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature