The Discordance of Gene Mutations between Circulating Tumor Cells and Primary/Metastatic Tumor.

ABSTRACT: Circulating tumor cells (CTCs) are an important part in the field of "liquid biopsy." However, major questions remain to be answered whether the mutations in the CTCs represent the mutations in primary tumor tissue and metastatic tumors. We compared the genetic mutations between CTCs and their matched tumors, and extracted data on the heterogeneity of the mutational status in CTCs and the change in mutations of CTCs before and during treatment. For mutations detected in single genes, we calculated the concordance of the mutations between the CTCs and primary tumor tissue. For mutations detected in multiple genes, we calculated the concordance of the mutations between the CTCs and primary/metastatic tumor tissue. The heterogeneity of the mutational status is clearly present in CTCs. For mut

SUBMITTER: Wang Q 

PROVIDER: S-EPMC6804648 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature