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Treatment of neuroendocrine carcinoma of the cervix with a PARP inhibitor based on next generation sequencing.

ABSTRACT: •This case reports the treatment of neuroendocrine carcinoma of the cervix with a PARPi based on NGS.•NGS reports have demonstrated somatic mutations BRCA in neuroendocrine carcinoma of the cervix.•The use of a PARPi in neuroendocrine carcinoma of the cervix has not been previously reported.

SUBMITTER: Rose PG 

PROVIDER: S-EPMC6804835 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Treatment of neuroendocrine carcinoma of the cervix with a PARP inhibitor based on next generation sequencing.

Rose Peter G PG   Sierk Anne A  

Gynecologic oncology reports 20190912

•This case reports the treatment of neuroendocrine carcinoma of the cervix with a PARPi based on NGS.•NGS reports have demonstrated somatic mutations BRCA in neuroendocrine carcinoma of the cervix.•The use of a PARPi in neuroendocrine carcinoma of the cervix has not been previously reported. ...[more]

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