Immunotherapy of Relapsed and Refractory Solid Tumors With Ex Vivo Expanded Multi-Tumor Associated Antigen Specific Cytotoxic T Lymphocytes: A Phase I Study.

ABSTRACT:

Purpose

Tumor-associated antigen cytotoxic T cells (TAA-Ts) represent a new, potentially effective and nontoxic therapeutic approach for patients with relapsed or refractory solid tumors. In this first-in-human trial, we investigated the safety of administering TAA-Ts that target Wilms tumor gene 1, preferentially expressed antigen of melanoma, and survivin to patients with relapsed/refractory solid tumors.

Materials and methods

TAA-T products were generated from autologous peripheral blood and infused over three dose levels: 1, 2, and 4 × 10⁷ cells/m². Patients were eligible for up to eight infusions administered 4 to 7 weeks apart. We assessed dose limiting toxicity during the first 45 days after infusion. Disease response was determined within the co

SUBMITTER: Hont AB 

PROVIDER: S-EPMC6804838 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature