Development and Validation of a Cytogenetic Prognostic Index Predicting Survival in Multiple Myeloma.

ABSTRACT:

Purpose

The wide heterogeneity in multiple myeloma (MM) outcome is driven mainly by cytogenetic abnormalities. The current definition of high-risk profile is restrictive and oversimplified. To adapt MM treatment to risk, we need to better define a cytogenetic risk classification. To address this issue, we simultaneously examined the prognostic impact of del(17p); t(4;14); del(1p32); 1q21 gain; and trisomies 3, 5, and 21 in a cohort of newly diagnosed patients with MM.

Methods

Data were obtained from 1,635 patients enrolled in four trials implemented by the Intergroupe Francophone du Myélome. The oldest collection of data were used for model development and internal validation. For external validation, one of the two independent data sets was used to assess the performance of

SUBMITTER: Perrot A 

PROVIDER: S-EPMC6804890 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature