A Carbonic Anhydrase Pseudogene Sensitizes Select Brucella Lineages to Low CO₂ Tension.

ABSTRACT: Brucella spp. are intracellular pathogens that cause a disease known as brucellosis. Though the genus is highly monomorphic at the genetic level, species have animal host preferences and some defining physiologic characteristics. Of note is the requirement for CO₂ supplementation to cultivate particular species, which confounded early efforts to isolate B. abortus from diseased cattle. Differences in the capacity of Brucella species to assimilate CO₂ are determined by mutations in the carbonic anhydrase gene, bcaA Ancestral single-nucleotide insertions in bcaA have resulted in frameshifted pseudogenes in B. abortus and B. ovis lineages, which underlie their inability to grow under the low CO₂ tension of a sta

SUBMITTER: Varesio LM 

PROVIDER: S-EPMC6805109 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature