Phosphatidylcholine Biosynthesis in Mitis Group Streptococci via Host Metabolite Scavenging.

ABSTRACT: The mitis group streptococci include the major human pathogen Streptococcus pneumoniae and the opportunistic pathogens Streptococcus mitis and Streptococcus oralis, which are human oral cavity colonizers and agents of bacteremia and infective endocarditis in immunocompromised patients. Bacterial membrane lipids play crucial roles in microbe-host interactions; for many pathogens, however, the composition of the membrane is poorly understood. In this study, we characterized the lipidomes of selected species of mitis group streptococci and investigated the mechanistic basis for biosynthesis of the phospholipid phosphatidylcholine (PC). PC is a major lipid in eukaryotic cellular membranes, but it is considered to be comparatively rare in bacterial taxa. Using liquid chroma

SUBMITTER: Joyce LR 

PROVIDER: S-EPMC6805115 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature