Neural evidence for age-related differences in representational quality and strategic retrieval processes.

ABSTRACT: Mounting behavioral evidence suggests that declines in both representational quality and controlled retrieval processes contribute to episodic memory decline with age. The present study sought neural evidence for age-related change in these factors by measuring neural differentiation during encoding of paired associates and changes in regional blood oxygenation level-dependent activity and functional connectivity during retrieval conditions that placed low (intact pairs) and high (recombined pairs) demands on controlled retrieval processes. Pattern similarity analysis revealed age-related declines in the differentiation of stimulus representations at encoding, manifesting as both reduced pattern similarity between closely related events and increased pattern similarity between distinct eve

SUBMITTER: Trelle AN 

PROVIDER: S-EPMC6805220 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature