Population Gene Introgression and High Genome Plasticity for the Zoonotic Pathogen Streptococcus agalactiae.

ABSTRACT: The influence that bacterial adaptation (or niche partitioning) within species has on gene spillover and transmission among bacterial populations occupying different niches is not well understood. Streptococcus agalactiae is an important bacterial pathogen that has a taxonomically diverse host range making it an excellent model system to study these processes. Here, we analyze a global set of 901 genome sequences from nine diverse host species to advance our understanding of these processes. Bayesian clustering analysis delineated 12 major populations that closely aligned with niches. Comparative genomics revealed extensive gene gain/loss among populations and a large pan genome of 9,527 genes, which remained open and was strongly partitioned among niches. As a result, the biochemical char

SUBMITTER: Richards VP 

PROVIDER: S-EPMC6805230 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature